Which post-marketing database and studies does EMEA require

Which post-marketing database and studies does EMEA require.

The European process for assessment of pharmaceutical products is complex and presents with diVerent levels. There is the European level with two major procedures resulting in decisions on approval after applications to market a pharmaceutical product in European countries. One is the centralised procedure organised by the European Medicines Evaluation Agency (EMEA). The other one is the mutual...

Further studies on mutant strains of Ophiostoma which require guanine.

Biochemical mutants which require guanine but are unable to utilize adenine and hypoxanthine obviously represent a very rare type of purine deficiency in microorganisms. So far, guanineless mutations have been observed only in the ascomycet,ous fungus, Ophiostoma multiannulatum, in which seven strains of this biochemical type were isolated after x-ray or ultraviolet irradiation (l-3). Three of ...

Does Modernization Require

Which Metaphor for Which Database?

The role of the users and their needs are now recognized in the database community. Many efforts are devoted to improve the quality of the interaction between the user and the database. For designing better interfaces that make the systems more usable, the use of suitable metaphors is crucial. The problem we address in this paper is whether an appropriate notion of metaphor can be tailored to t...

Does intelligence require a body?

Our brain controls our body—every movement we make is guided by neuronal activity. But how about vice versa? Does the body influence our brain; does it have an impact on how we think? This question might seem odd. We usually stick to a simple ‘sense– think–act’ paradigm: we hear the phone ring (sense), we recognize that we should answer it (think) and grab the receiver (act). This is a one-way ...